ACO1 / Aconitase

Aconitase 1

IRP1 / Aconitase is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants

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Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

ACO1 / Aconitase (13)

Publications

No (13)

Tag

GST (1)

GST, N-terminus (1)

His (8)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (7)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human ACO1 / Aconitase Protein (Recombinant His) (Met1-Lys889) - LS-G97117

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

101 kDa

Price:

50 µg/$854

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Human ACO1 / Aconitase Protein (Recombinant His) (aa26-243) - LS-G16031

Source:

E. coli

Tag:

His

Molecular Weight:

26.2 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Human ACO1 / Aconitase Protein (Recombinant His) (aa251-443) - LS-G16032

Source:

E. coli

Tag:

His

Molecular Weight:

22.5 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Human ACO1 / Aconitase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66113

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

20 µg/$1,107

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Human ACO1 / Aconitase Protein (Recombinant GST, N-terminus) (aa780-889) - LS-G57679

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ACO1 / Aconitase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76942

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

20 µg/$150

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ACO1 / Aconitase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99681

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

100 µg/$494

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Mouse ACO1 / Aconitase Protein (Recombinant His) (aa26-189) - LS-G16034

Source:

E. coli

Tag:

His

Molecular Weight:

20.4 kDa

Price:

10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430

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Human ACO1 / Aconitase Protein (Recombinant His) (aa458-586) - LS-G16035

Source:

E. coli

Tag:

His

Molecular Weight:

15.2 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,801

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Mouse ACO1 / Aconitase Protein (Recombinant His) (aa527-719) - LS-G16039

Source:

E. coli

Tag:

His

Molecular Weight:

23.0 kDa

Price:

10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430

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Human ACO1 / Aconitase Protein (Recombinant His) (aa669-834) - LS-G16033

Source:

E. coli

Tag:

His

Molecular Weight:

19.2 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Human ACO1 / Aconitase Protein (Recombinant GST) (Full Length) - LS-G27332

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

124.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ACO1 / Aconitase Protein (Recombinant His) - LS-G1093

Source:

E. coli

Tag:

His

Price:

10 µg/$292; 50 µg/$411; 20 µg/$361; 100 µg/$544; 250 µg/$954; 500 µg/$1,447

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