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Vector Laboratories, Inc.
6737 Mowry Ave
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ACO1 / Aconitase
Aconitase 1
IRP1 / Aconitase is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
| Gene Name: | Aconitase 1 |
| Synonyms: | ACO1, ACONS, Aconitase, Aconitase 1, soluble, Aconitate hydratase, Citrate hydro-lyase, IREB1, IRE-BP 1, IREBP, IRP1, Ferritin repressor protein, IREBP1, Iron regulatory protein 1 |
| Target Sequences: | NM_002197 NP_002188.1 P21399 |
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Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
101 kDa
50 µg/$854
ACO1 / Aconitase Mouse anti-Human Monoclonal (2C1) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
ACO1 / Aconitase Rabbit anti-Human Polyclonal (aa106-155) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
ACO1 / Aconitase Rabbit anti-Human Polyclonal (pSer711) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ACO1 / Aconitase Goat anti-Human Polyclonal (aa30-44) Antibody
Rabbit, Mouse, Rat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ACO1 / Aconitase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
ACO1 / Aconitase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
ACO1 / Aconitase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACO1 / Aconitase Rabbit anti-Human Polyclonal (80-160 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACO1 / Aconitase Rabbit anti-Human Polyclonal (Ab-138) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
ACO1 / Aconitase Rabbit anti-Human Polyclonal (Arg134) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
ACO1 / Aconitase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ACO1 / Aconitase Rabbit anti-Human Polyclonal (pSer711) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ACO1 / Aconitase Rabbit anti-Human Polyclonal (650-730 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ICC, IP, WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ICC, IP, WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ICC, IP, WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse
ICC, IP, WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse
ICC, IP, WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody
Mouse
ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
ACO1 / Aconitase Rabbit anti-Mouse Polyclonal (Cy3) Antibody
Mouse
ICC, IP, WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
ACO1 / Aconitase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ACO1 / Aconitase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Zebrafish, Rat, Bovine, Rabbit, Mouse, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
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product results
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