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ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Gene Name: | ATP citrate lyase |
Synonyms: | ACLY, ACL, ATP citrate synthase, ATPCL, ATP citrate lyase, ATP-citrate (pro-S-)-lyase, CLATP, ATP-citrate synthase, Citrate cleavage enzyme, Citrate Lyase |
Target Sequences: | NM_001096 NP_001087.2 P53396 |
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