ACKR4 / CCRL1 / CCR11

atypical chemokine receptor 4

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

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Proteins (1)

Type

Recombinant (1)

Target

ACKR4 / CCRL1 / CCR11 (1)

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No (1)

Tag

GST (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

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Purified (1)

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Human ACKR4 / CCRL1 / CCR11 Protein (Recombinant GST) (Full Length) - LS-G33818

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.3 kDa

Price:

2 µg/$439

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