ACKR1 / DARC

Duffy blood group, atypical chemokine receptor

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

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Products

Antibodies (59)

Proteins (7)

ELISA Kits (1)

Type

Over-Expression Lysate (4)

Primary (59)

Recombinant (3)

Sandwich (1)

Target

ACKR1 / DARC (67)

Reactivity

Human (51)

Mouse (26)

Rat (11)

Application

IHC (14)

IHC-P (8)

WB (53)

Flo (4)

Block (2)

ELISA (17)

ICC (2)

IF (6)

IP (1)

Peptide-ELISA (3)

Host

rabbit (53)

mouse (4)

goat (1)

sheep (1)

Product Group

IHCPlus (2)

Isotype

IgG (39)

IgG,k (1)

IgG1,k (1)

IgG2a (2)

Clonality

monoclonal mc (2)

polyclonal pc (55)

recombinant monoclonal rmc (2)

Clone

2C3 (2)

358307 (2)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (8)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (6)

Unconjugated (26)

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Epitope

aa71-330 (8)

aa1-30 (7)

N-Terminus (6)

aa1-63 (4)

C-Terminus (3)

DARC (2)

10-90 aa, N-terminal (1)

N-Terminal (1)

aa1-50 (1)

aa1-61 (1)

Publications

No (67)

Sample Type

Cell Lysates (1)

Plasma (1)

Serum (1)

Tag

GST (1)

His-GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ ACKR1 / DARC Antibody (aa1-50) LS-B6122

(4.0) Rating

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ ACKR1 / DARC Antibody LS-B2306

(4.0) Rating

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$545

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ACKR1 / DARC Antibody (aa1-63) LS-C371451

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (aa1-63) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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ACKR1 / DARC Antibody (DARC, clone 2C3) LS-C777411

Antibody:

ACKR1 / DARC Mouse anti-Human Recombinant Monoclonal (DARC) (2C3) Antibody

Reactivity:

Human

Applications:

Block, ELISA, Flo

Format:

Unconjugated

Price:

0.2 mg/$540

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ACKR1 / DARC Antibody (N-Terminus) LS-C354318

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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ACKR1 / DARC Antibody (DARC, clone 2C3) LS-C777410

Antibody:

ACKR1 / DARC Rabbit anti-Human Recombinant Monoclonal (DARC) (2C3) Antibody

Reactivity:

Human

Applications:

Block, ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

0.2 mg/$540

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ACKR1 / DARC Antibody LS-C19691

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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ACKR1 / DARC Antibody (C-Terminus) LS-C121174

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$729

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ACKR1 / DARC Antibody (Biotin) LS-C525442

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$907

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ACKR1 / DARC Antibody (FITC) LS-C535458

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$907

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ACKR1 / DARC Antibody (PE) LS-C653643

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

PE Conjugated

Price:

100 µl/$907

• Unconjugated
• Biotin
• FITC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • PE

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ACKR1 / DARC Antibody (aa71-330) LS-C293715

Antibody:

ACKR1 / DARC Rabbit anti-Mouse Polyclonal (aa71-330) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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ACKR1 / DARC Antibody (aa1-30) LS-C157679

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse ACKR1 / DARC Protein (Recombinant His-GST) (aa71-330) - LS-G14143

Source:

E. coli

Tag:

His-GST

Molecular Weight:

60.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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ACKR1 / DARC Antibody LS-C664987

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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ACKR1 / DARC Antibody (clone 358307) LS-C36136

Antibody:

ACKR1 / DARC Mouse anti-Human Monoclonal (358307) Antibody

Reactivity:

Human

Applications:

Flo, ICC

Format:

Unconjugated

Price:

100 µg/$896

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ACKR1 / DARC Antibody (N-Terminus) LS-C121175

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$688

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ACKR1 / DARC Antibody (Biotin) LS-C525444

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$973

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ACKR1 / DARC Antibody (FITC) LS-C535460

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$973

Select

ACKR1 / DARC Antibody (PE) LS-C653642

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

PE Conjugated

Price:

100 µl/$973

• Unconjugated
• Biotin
• FITC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • PE

Select

ACKR1 / DARC Antibody (clone 358307, PE) LS-C36137

Antibody:

ACKR1 / DARC Mouse anti-Human Monoclonal (PE) (358307) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P

Format:

PE Conjugated

Price:

100 Tests/$832

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ACKR1 / DARC Antibody (10-90 aa, N-terminal) LS-C383219

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ACKR1 / DARC Antibody LS-C822181

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

100 µg/$357

Select

ACKR1 / DARC Antibody (aa1-30) LS-C320747

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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ACKR1 / DARC Antibody (aa1-30, FITC) LS-C222003

Antibody:

ACKR1 / DARC Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC

• Unconjugated
• FITC

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