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ACHE / Acetylcholinesterase

acetylcholinesterase

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.

Gene Name: acetylcholinesterase
Synonyms: ACHE, ACEE, Acetylcholinesterase, N-ACHE, Yt blood group, ARACHE, YT
Target Sequences: NM_015831 P22303 P22303

Publications (1)

1
Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. Yiyu Wang, Jörg Scheffel, Carolina Ayala Vera, Wei Liu, Dorothee Günzel, Dorothea Terhorst-Molawi, Marcus Maurer, Sabine Altrichter. Frontiers in immunology. 2022 August;13:955161. [Full Text Article] [PubMed:35967390] [PMC:PMC9373796] Related Antibodies: LS-B6676.

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Antibodies (115)
Primary (115)
ACHE / Acetylcholinesterase (115)
Human (68)
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aa377-574 (16)
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ACHE / Acetylcholinesterase Antibody - Anti-Acetylcholinesterase antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACHE / Acetylcholinesterase Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (aa536-585) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ACHE / Acetylcholinesterase Antibody - Anti-Acetylcholinesterase antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
ACHE / Acetylcholinesterase Antibody - Anti-Acetylcholinesterase antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACHE / Acetylcholinesterase Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$485
ACHE / Acetylcholinesterase Antibody - ACHE / Acetylcholinesterase antibody immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing vesicle staining. The nuclear stain is DAPI (blue).
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ACHE / Acetylcholinesterase Goat anti-Human Polyclonal (aa601-614) Antibody
Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
ACHE / Acetylcholinesterase Antibody - Western blot of AChE antibody
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACHE / Acetylcholinesterase Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with ACHE antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (aa147-175) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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ACHE / Acetylcholinesterase Rabbit anti-Electric eel Polyclonal Antibody
Electric eel
ELISA, WB
Unconjugated
1 ml/$694
ACHE / Acetylcholinesterase Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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Neuroscience
ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ACHE / Acetylcholinesterase Rabbit anti-Electric eel Polyclonal Antibody
Electric eel
DB, ELISA, IF, WB
Unconjugated
10 mg/$335
ACHE / Acetylcholinesterase Antibody - Western blot of AChE (K585) pAb in extracts from Jurkat cells.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (Lys585) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
ACHE / Acetylcholinesterase Antibody - AChE antibody detects ACHE protein at cytoplasm on colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. AChE antibody dilution:1:500.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal (aa406-614) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
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ACHE / Acetylcholinesterase Rabbit anti-Electric eel Polyclonal Antibody
Electric eel
ELISA, IF, IHC, WB
Unconjugated
1 mg/$520
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ACHE / Acetylcholinesterase Rabbit anti-Electric eel Polyclonal (Biotin) Antibody
Electric eel
ELISA, IF, IHC, WB
Biotin Conjugated
1 ml/$438
ACHE / Acetylcholinesterase Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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ACHE / Acetylcholinesterase Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ACHE / Acetylcholinesterase Antibody - Western blot of recombinant ACHE / Acetylcholinesterase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACHE / Acetylcholinesterase Mouse anti-Human Monoclonal (aa377-574) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$492; 1 ml/$563; 2 ml/$758; 5 ml/$1,233
ACHE / Acetylcholinesterase Antibody - Western blot of recombinant ACHE / Acetylcholinesterase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACHE / Acetylcholinesterase Mouse anti-Human Monoclonal (aa377-574) (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
100 µl/$339; 200 µl/$394; 500 µl/$577; 1 ml/$705; 2 ml/$942; 5 ml/$1,603
ACHE / Acetylcholinesterase Antibody - Western blot of recombinant ACHE / Acetylcholinesterase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACHE / Acetylcholinesterase Mouse anti-Human Monoclonal (aa377-574) (Biotin) Antibody
Human
ICC, IP, WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$520; 1 ml/$598; 2 ml/$828; 5 ml/$1,356
ACHE / Acetylcholinesterase Antibody - Western blot of recombinant ACHE / Acetylcholinesterase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACHE / Acetylcholinesterase Mouse anti-Human Monoclonal (aa377-574) (FITC) Antibody
Human
ICC, IP, WB
FITC Conjugated
100 µl/$348; 200 µl/$408; 500 µl/$608; 1 ml/$758; 2 ml/$996; 5 ml/$1,725
ACHE / Acetylcholinesterase Antibody - Western blot of recombinant ACHE / Acetylcholinesterase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACHE / Acetylcholinesterase Mouse anti-Human Monoclonal (aa377-574) (Cy3) Antibody
Human
ICC, IP, WB
Cy3 Conjugated
100 µl/$407; 200 µl/$492; 500 µl/$853; 1 ml/$1,013; 2 ml/$1,315; 5 ml/$2,465
ACHE / Acetylcholinesterase Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
ACHE / Acetylcholinesterase Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ACHE / Acetylcholinesterase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).