Products

Research Areas

COVID-19

Resources

Quick Order

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

Cart

Products

Antibodies

All Antibodies Primary Antibodies Secondary Antibodies IHC-plus™ Antibodies PathPlus™ Antibodies Isotype Control Antibodies

ELISA and Assay Kits

All Kits Assay Kits Traditional ELISA Kits Cell-Based ELISA Kits DNA-Binding ELISA Kits Phospho-Specific ELISA Kits ELISA Development Kits Chemiluminescent CLIA Kits

Proteins

All Proteins Recombinant Proteins Native Proteins Over-Expression Lysates Bio-Active Proteins Animal-Free Proteins Synthetic Peptides Cell and Tissue Lysates

Research Areas

Cancer Research

Breast Cancer IHC Colorectal Cancer IHC Lung Cancer IHC Prostate Cancer IHC

Pathways And Groups

Apoptosis Caspases Chemokines

Infectious Disease

Virology Coronaviridae (COVID-19) Hepatitis Viruses Herpesviridae (Herpes) Orthomyxoviridae (Influenza) Papillomaviridae (HPV) Paramyxoviridae (Mumps) Pneumoviridae (RSV) Polyomaviridae (SV40) Retroviridae (HIV) Togaviridae (Measles)

Neurodegenerative Disease

Alzheimer's Disease

COVID-19

Coronavirus Detection Coronavirus and COVID-19 Inhibitors Coronavirus Antibodies, Proteins, and cDNAs Cytokine Release Syndrome General Coronavirus Information

Resources

Purchasing

Product Ordering Terms and Conditions Holiday Schedule About the LSBio Guarantee About Reviews

Reference Material

About LSBio (LifeSpan BioSciences Inc.) About Our IHC Validation Process About Our IHC-plus™ Immunohistochemistry Protocol About Our Protocols LSBio ELISA Kit Development Guide Media

Secure Logins

How To Buy

Location

Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers

Customer Service: (800) 227-6666 / (650) 697-3600

Contact Us

Additional Contact Details

Distributors

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

ACE2 / ACE-2

angiotensin I converting enzyme 2

Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).

Gene Name:	angiotensin I converting enzyme 2
Family/Subfamily:	Protease , Metallopeptidase M2
Synonyms:	ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor
Target Sequences:	NM_021804 NP_068576.1 Q9BYF1

Publications (10)

Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human) [Full Text Article] [PubMed:23678171] [PMC:PMC3700180] Related Antibodies: LS-C122669.

Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension. Francine Duchatsch, Paula B Constantino, Naiara A Herrera, Mayara F Fabrício, Lidieli P Tardelli, Aline M Martuscelli, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral. Journal of the American Society of Hypertension : JASH. 2018 August;12:605-613. [Full Text Article] [PubMed:29945776]

Reduced severe acute respiratory syndrome coronavirus 2 entry factors and enhanced innate immune gene expression in the nasal epithelium of pregnant rats. Arvind Palanisamy, Tusar Giri. American journal of obstetrics and gynecology. 2020 October; [Full Text Article] [PubMed:33039392] [PMC:PMC7544630] Related Antibodies: LS-C763699.

Pregnancy as a "golden opportunity" for patient activation and engagement. Lynn M Yee, Melissa A Simon, William A Grobman, Priya V Rajan. American journal of obstetrics and gynecology. 2020 September; [Full Text Article] [PubMed:32979375] Related Antibodies: LS-C763699.

Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia. Emma N Bardsley, Oliver C Neely, David J Paterson. Journal of molecular and cellular cardiology. 2020 Jan;138:234-243. [Full Text Article] [PubMed:31836539] [PMC:PMC7049903]

Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions. bioRxiv : the preprint server for biology. 2021 Jul; [Full Text Article] [PubMed:34268510] [PMC:PMC8282098] Related Antibodies: LS-C275129.

Case series - COVID-19 is unlikely to affect male fertility: Results of histopathological and reverse transcriptase polymerase chain reaction analysis. John M Masterson, Chau Bui, Wohaib Hasan, Yi Zhang, Carissa Huynh, Harneet Jawanda, Daniel Luthringer, Warren Tourtellotte, Eric Vail, Maurice M Garcia. Canadian Urological Association journal. 2022 June; [Full Text Article] [PubMed:35704934] Related Antibodies: LS-B6672.

Exercise attenuates dexamethasone-induced hypertension through an improvement of baroreflex activity independently of the renin-angiotensin system. Paula B Constantino, Thiago J Dionísio, Francine Duchatsch, Naiara A Herrera, Josiane O Duarte, Carlos F Santos, Carlos C Crestani, Sandra L Amaral. Steroids. 2017 December;128:147-154. [Full Text Article] [PubMed:29054562] Related Antibodies: LS-C413153.

Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions. Mai M Abdelmoaty, Pravin Yeapuri, Jatin Machhi, Katherine E Olson, Farah Shahjin, Vikas Kumar, You Zhou, Jingjing Liang, Kabita Pandey, Arpan Acharya, Siddappa N Byrareddy, R Lee Mosley, Howard E Gendelman. Frontiers in immunology. 2021 October;12:741502. [Full Text Article] [PubMed:34671355] [PMC:PMC8521106] Related Antibodies: LS-C275129.

Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article] [PubMed:23462816] [PMC:PMC3625779] Related Antibodies: LS-B3197.

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Family of Companies