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ACD / PTOP

adrenocortical dysplasia homolog (mouse)

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.

Gene Name: adrenocortical dysplasia homolog (mouse)
Synonyms: ACD, PTOP, TIN2 interacting protein 1, TINT1, PIP1
Target Sequences: NM_022914 NP_075065.2 Q96AP0

Publications (1)

1
Transcriptome analyses of ovarian stroma: tunica albuginea, interstitium and theca interna. Katja Hummitzsch, Nicholas Hatzirodos, Anne M Macpherson, Jeff Schwartz, Raymond J Rodgers, Helen F Irving-Rodgers. Reproduction (Cambridge, England). 2019 Jun;;157:545-565. [Full Text Article] [PubMed:30925461] Related Antibodies: LS-C108067.

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ELISA Kits (6)
Sandwich (6)
ACD / PTOP (6)
Human (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
96-Well Strip Plate (6)
No (6)
Plasma (1)
Serum (1)
ACD / PTOP ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ACD / PTOP ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ACD / PTOP ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ACD / PTOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ACD / PTOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ACD / PTOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).