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ACCN1 / ASIC2

acid-sensing (proton-gated) ion channel 2

ACCN1 / ASIC2 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.

Gene Name: acid-sensing (proton-gated) ion channel 2
Family/Subfamily: Ion Channel , Sodium channel - amiloride-sensitive
Synonyms: ASIC2, ACCN1, ASIC2a, Brain sodium channel 1, Degenerin, ACCN, Acid-sensing ion channel 2, Mammalian degenerin homolog, MDEG, MDEG1, MDEG2, HBNaC1, BNaC1, MAMMALIAN DEGENERIN, ASIC2b
Target Sequences: NM_183377 NP_899233.1 Q16515

Publications (12)

1
Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage. Jingjing Su, Yuping Tang, Ling Liu, Houguang Zhou, Qiang Dong. Neuroscience letters. 2011 490:46-51. (WB; Human, Hamster) [Full Text Article] [PubMed:21167908] Related Antibodies: LS-C93915.
2
Immunohistochemical Detection of the Putative Mechanoproteins ASIC2 and TRPV4 in Avian Herbst Sensory Corpuscles. Cabo R, Gálvez A, Laurà R, San José I, Pastor JF, López-Muñiz A, García-Suárez O, Vega JA. Anatomical record (Hoboken, N.J. : 2007). 2013 296:117-22. (IHC-P; Pigeon) [PubMed:23152301] Related Antibodies: LS-C93915.
3
Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc. Cuesta A, Viña E, Cabo R, Vázquez G, Cobo R, García-Suárez O, García-Cosamalón J, Vega JA. International journal of clinical and experimental pathology. 2015 8:10305-14. (WB; Human) [PubMed:26617738] [PMC:PMC4637553] Related Antibodies: LS-B156.
4
Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. Mohamed Farrag, Julie K Drobish, Henry L Puhl, Joyce S Kim, Paul B Herold, Marc P Kaufman, Victor Ruiz-Velasco. The Journal of physiology. 2017 December;595:7167-7183. [Full Text Article] [PubMed:29044528] [PMC:PMC5709321] Related Antibodies: LS-C110053.
5
Acid-sensing ion channels in healthy and degenerated human intervertebral disc. Cuesta A, Del Valle ME, Garc[Character ed]a-Su[Character e1]rez O, Vi[Character f1]a E, Cabo R, V[Character e1]zquez G, Cobo JL, Murcia A, Alvarez-Vega M, Garc[Character ed]a-Cosamal[Character f3]n J, Vega JA. Connective tissue research. 2014 Jun;55:197-204. [Full Text Article] [PubMed:24432912] Related Antibodies: LS-B156.
6
Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish. Vi[Character f1]a E, Parisi V, Cabo R, Laur[Character e0] R, L[Character f3]pez-Velasco S, L[Character f3]pez-Mu[Character f1]iz A, Garc[Character ed]a-Su[Character e1]rez O, German[Character e0] A, Vega JA. Neuroscience letters. 2013 Mar;536:35-40. [Full Text Article] [PubMed:23328442] Related Antibodies: LS-B156.
7
Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish. Parisi V, S[Character e1]nchez-Ramos C, Cabo R, Guerrera MC, Quir[Character f3]s LM, German[Character e0] A, Vega JA, Garc[Character ed]a-Su[Character e1]rez O. Cell and tissue research. Jan; [Full Text Article] [PubMed:25585988] Related Antibodies: LS-B156.
8
Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. Vi[Character f1]a E, Parisi V, Abbate F, Cabo R, Guerrera MC, Laur[Character e0] R, Quir[Character f3]s LM, P[Character e9]rez-Varela JC, Cobo T, German[Character e0] A, Vega JA, Garc[Character ed]a-Su[Character e1]rez O. Histochemistry and cell biology. 2015 Jan;143:59-68. [Full Text Article] [PubMed:25161120] Related Antibodies: LS-B156.
9
The sensory innervation of the human pharynx: searching for mechanoreceptors. de Carlos F, Cobo J, Mac[Character ed]as E, Feito J, Cobo T, Calavia MG, Garc[Character ed]a-Su[Character e1]rez O, Vega JA. Anatomical record (Hoboken, N.J. : 2007). 2013 Nov;296:1735-46. [Full Text Article] [PubMed:24123994] Related Antibodies: LS-C93915.
10
Acid-sensing ion channel 2 (ASIC2) in the intestine of adult zebrafish. Levanti MB, Guerrera MC, Calavia MG, Ciriaco E, Montalbano G, Cobo J, German[Character e0] A, Vega JA. Neuroscience letters. 2011 Apr;494:24-8. [Full Text Article] [PubMed:21356277] Related Antibodies: LS-C93915.
11
Immunohistochemical localization of acid-sensing ion channel 2 (ASIC2) in cutaneous Meissner and Pacinian corpuscles of Macaca fascicularis. Cabo R, G[Character e1]lvez MA, San Jos[Character e9] I, Laur[Character e0] R, L[Character f3]pez-Mu[Character f1]iz A, Garc[Character ed]a-Su[Character e1]rez O, Cobo T, Insausti R, Vega JA. Neuroscience letters. 2012 May;516:197-201. [Full Text Article] [PubMed:22708125] Related Antibodies: LS-C93915.
12
ASIC2 is present in human mechanosensory neurons of the dorsal root ganglia and in mechanoreceptors of the glabrous skin. Cabo R, Alonso P, Vi[Character f1]a E, V[Character e1]zquez G, Gago A, Feito J, P[Character e9]rez-Molt[Character f3] FJ, Garc[Character ed]a-Su[Character e1]rez O, Vega JA. Histochemistry and cell biology. Mar;143:267-76. [Full Text Article] [PubMed:25224144] Related Antibodies: LS-C93915.
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ACCN1 / ASIC2 Protein - Purified recombinant protein ASIC2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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ACCN1 / ASIC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104022
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Human ACCN1 / ASIC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74470
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Human ACCN1 / ASIC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74471
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