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ACCN1 / ASIC2

acid-sensing (proton-gated) ion channel 2

ACCN1 / ASIC2 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.

Gene Name:	acid-sensing (proton-gated) ion channel 2
Family/Subfamily:	Ion Channel , Sodium channel - amiloride-sensitive
Synonyms:	ASIC2, ACCN1, ASIC2a, Brain sodium channel 1, Degenerin, ACCN, Acid-sensing ion channel 2, Mammalian degenerin homolog, MDEG, MDEG1, MDEG2, HBNaC1, BNaC1, MAMMALIAN DEGENERIN, ASIC2b
Target Sequences:	NM_183377 NP_899233.1 Q16515

Publications (12)

Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage. Jingjing Su, Yuping Tang, Ling Liu, Houguang Zhou, Qiang Dong. Neuroscience letters. 2011 490:46-51. (WB; Human, Hamster) [Full Text Article] [PubMed:21167908] Related Antibodies: LS-C93915.

Immunohistochemical Detection of the Putative Mechanoproteins ASIC2 and TRPV4 in Avian Herbst Sensory Corpuscles. Cabo R, Gálvez A, Laurà R, San José I, Pastor JF, López-Muñiz A, García-Suárez O, Vega JA. Anatomical record (Hoboken, N.J. : 2007). 2013 296:117-22. (IHC-P; Pigeon) [PubMed:23152301] Related Antibodies: LS-C93915.

Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc. Cuesta A, ViÃ±a E, Cabo R, Vázquez G, Cobo R, García-Suárez O, García-Cosamalón J, Vega JA. International journal of clinical and experimental pathology. 2015 8:10305-14. (WB; Human) [PubMed:26617738] [PMC:PMC4637553] Related Antibodies: LS-B156.

Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. Mohamed Farrag, Julie K Drobish, Henry L Puhl, Joyce S Kim, Paul B Herold, Marc P Kaufman, Victor Ruiz-Velasco. The Journal of physiology. 2017 December;595:7167-7183. [Full Text Article] [PubMed:29044528] [PMC:PMC5709321] Related Antibodies: LS-C110053.

Acid-sensing ion channels in healthy and degenerated human intervertebral disc. Cuesta A, Del Valle ME, Garc[Character ed]a-Su[Character e1]rez O, Vi[Character f1]a E, Cabo R, V[Character e1]zquez G, Cobo JL, Murcia A, Alvarez-Vega M, Garc[Character ed]a-Cosamal[Character f3]n J, Vega JA. Connective tissue research. 2014 Jun;55:197-204. [Full Text Article] [PubMed:24432912] Related Antibodies: LS-B156.

Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish. Vi[Character f1]a E, Parisi V, Cabo R, Laur[Character e0] R, L[Character f3]pez-Velasco S, L[Character f3]pez-Mu[Character f1]iz A, Garc[Character ed]a-Su[Character e1]rez O, German[Character e0] A, Vega JA. Neuroscience letters. 2013 Mar;536:35-40. [Full Text Article] [PubMed:23328442] Related Antibodies: LS-B156.

Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish. Parisi V, S[Character e1]nchez-Ramos C, Cabo R, Guerrera MC, Quir[Character f3]s LM, German[Character e0] A, Vega JA, Garc[Character ed]a-Su[Character e1]rez O. Cell and tissue research. Jan; [Full Text Article] [PubMed:25585988] Related Antibodies: LS-B156.

Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. Vi[Character f1]a E, Parisi V, Abbate F, Cabo R, Guerrera MC, Laur[Character e0] R, Quir[Character f3]s LM, P[Character e9]rez-Varela JC, Cobo T, German[Character e0] A, Vega JA, Garc[Character ed]a-Su[Character e1]rez O. Histochemistry and cell biology. 2015 Jan;143:59-68. [Full Text Article] [PubMed:25161120] Related Antibodies: LS-B156.

The sensory innervation of the human pharynx: searching for mechanoreceptors. de Carlos F, Cobo J, Mac[Character ed]as E, Feito J, Cobo T, Calavia MG, Garc[Character ed]a-Su[Character e1]rez O, Vega JA. Anatomical record (Hoboken, N.J. : 2007). 2013 Nov;296:1735-46. [Full Text Article] [PubMed:24123994] Related Antibodies: LS-C93915.

Acid-sensing ion channel 2 (ASIC2) in the intestine of adult zebrafish. Levanti MB, Guerrera MC, Calavia MG, Ciriaco E, Montalbano G, Cobo J, German[Character e0] A, Vega JA. Neuroscience letters. 2011 Apr;494:24-8. [Full Text Article] [PubMed:21356277] Related Antibodies: LS-C93915.

Immunohistochemical localization of acid-sensing ion channel 2 (ASIC2) in cutaneous Meissner and Pacinian corpuscles of Macaca fascicularis. Cabo R, G[Character e1]lvez MA, San Jos[Character e9] I, Laur[Character e0] R, L[Character f3]pez-Mu[Character f1]iz A, Garc[Character ed]a-Su[Character e1]rez O, Cobo T, Insausti R, Vega JA. Neuroscience letters. 2012 May;516:197-201. [Full Text Article] [PubMed:22708125] Related Antibodies: LS-C93915.

ASIC2 is present in human mechanosensory neurons of the dorsal root ganglia and in mechanoreceptors of the glabrous skin. Cabo R, Alonso P, Vi[Character f1]a E, V[Character e1]zquez G, Gago A, Feito J, P[Character e9]rez-Molt[Character f3] FJ, Garc[Character ed]a-Su[Character e1]rez O, Vega JA. Histochemistry and cell biology. Mar;143:267-76. [Full Text Article] [PubMed:25224144] Related Antibodies: LS-C93915.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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