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ACAN / Aggrecan
aggrecan
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
| Gene Name: | aggrecan |
| Synonyms: | ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG |
| Target Sequences: | NM_013227 NP_037359.3 P16112 |
Publications (5)
1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88.
[PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat)
[PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat)
[PubMed:22394620]
[PMC:PMC3446417]
☰ Filters
Products
Proteins
(11)
Type
Recombinant
(11)
Target
ACAN / Aggrecan
(11)
Publications
No
(11)
Tag
GST
(1)
GST, N-terminus
(1)
His
(5)
His, N-Terminal
(1)
His-S
(1)
His-T7
(1)
Species
Bovine
(1)
Human
(6)
Mouse
(2)
Rat
(2)
Source
E. coli
(8)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(1)
Low Endotoxin Level
Low endotoxin level
(1)
E. coli
His
20.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
E. coli
His
14.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
HEK 293 Cells
None
Less than 0.1 EU/µg protein (determined by LAL method).
This 672 amino acid recombinant protein with a C-terminal His tag has a predicted molecular mass of approximately 74.3 kD. The protein migrates at about 100 kD by SDS-PAGE in DTT-reducing and non-reducing conditions. The predicted N-terminal amino acid is
25 µg/$375; 100 µg/$731
E. coli
His
12.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His-S
18.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
14.1 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
E. coli
His
12.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His, N-Terminal
23.7kDa
10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
E. coli
His-T7
33.3 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Wheat Germ Extract
GST
106 kDa
2 µg/$439
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