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Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1.
Gene Name: | acetyl-CoA carboxylase beta |
Synonyms: | ACACB, ACCB, ACC-beta, ACC2, Acetyl-CoA carboxylase 2, Acetyl-CoA carboxylase beta, HACC275 |
Target Sequences: | NM_001093 NP_001084.3 O00763 |
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