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Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Gene Name: | alkB, alkylation repair homolog 2 (E. coli) |
Synonyms: | ALKBH2, 2OG-Fe(II) oxy DC1, ABH2, Oxy DC1 |
Target Sequences: | Q6NS38 Q6NS38 |
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