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ABCG8

ATP-binding cassette, sub-family G (WHITE), member 8

ABCG8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.

Gene Name: ATP-binding cassette, sub-family G (WHITE), member 8
Family/Subfamily: Transporter , ATP-binding cassette - ABCG/WHITE
Synonyms: ABCG8, Sterolin-2, STSL, GBD4, Sterolin 2
Target Sequences: NM_022437 NP_071882.1 Q9H221

Publications (3)

1
Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, Arai H, Ueda K, Matsuo M. Journal of lipid research. 2006 47:1791-802. [PubMed:16702602]
2
Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid. Mathur SN, Watt KR, Field FJ. Journal of lipid research. 2007 48:395-404. [PubMed:17114806]
3
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]

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Proteins (4)
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ABCG8 (4)
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His-T7, N-terminus (2)
Myc-DDK (Flag) (2)
Human (1)
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293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
ABCG8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
75.5 kDa
20 µg/$215
ABCG8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
75.5 kDa
100 µg/$710
ABCG8 Protein - Recombinant ATP Binding Cassette Transporter G8 (ABCG8) by SDS-PAGE
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E. coli
His-T7, N-terminus
34.0kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
ABCG8 Protein - Recombinant ATP Binding Cassette Transporter G8 (ABCG8) by SDS-PAGE
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E. coli
His-T7, N-terminus
34.1kDa
10 µg/$276; 50 µg/$412; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).