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ABCG8

ATP-binding cassette, sub-family G (WHITE), member 8

ABCG8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.

Gene Name: ATP-binding cassette, sub-family G (WHITE), member 8
Family/Subfamily: Transporter , ATP-binding cassette - ABCG/WHITE
Synonyms: ABCG8, Sterolin-2, STSL, GBD4, Sterolin 2
Target Sequences: NM_022437 NP_071882.1 Q9H221

Publications (3)

1
Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, Arai H, Ueda K, Matsuo M. Journal of lipid research. 2006 47:1791-802. [PubMed:16702602]
2
Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid. Mathur SN, Watt KR, Field FJ. Journal of lipid research. 2007 48:395-404. [PubMed:17114806]
3
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]

☰ Filters
Products
Antibodies (43)
Primary (43)
ABCG8 (43)
Human (22)
Mouse (23)
Rat (13)
IHC (9)
IHC-P (7)
WB (40)
ELISA (5)
ICC (5)
IF (2)
IP (5)
Peptide-ELISA (1)
rabbit (38)
mouse (5)
Product Group
IHCPlus (1)
IgG (15)
monoclonal mc (5)
polyclonal pc (38)
1B10A5 (5)
APC (2)
APC Conjugated (2)
Biotin Conjugated (6)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
DY488 Conjugated (3)
DY550 Conjugated (3)
DY650 Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (14)
N-Terminus (13)
No (43)
ABCG8 Antibody - Immunohistochemistry: ABCG8 Antibody (1B10A5) - IHC of ABCG8 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Mouse anti-Mouse Monoclonal (1B10A5) Antibody
Mouse
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$386
ABCG8 Antibody - Immunohistochemistry: ABCG8 Antibody (1B10A5) - IHC of ABCG8 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Mouse anti-Mouse Monoclonal (Biotin) (1B10A5) Antibody
Mouse, Human
ICC, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
ABCG8 Antibody - Immunohistochemistry: ABCG8 Antibody (1B10A5) - IHC of ABCG8 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Mouse anti-Mouse Monoclonal (DY650) (1B10A5) Antibody
Mouse
ICC, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
ABCG8 Antibody - Immunohistochemistry: ABCG8 Antibody (1B10A5) - IHC of ABCG8 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Mouse anti-Mouse Monoclonal (DY488) (1B10A5) Antibody
Mouse
ICC, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
ABCG8 Antibody - Immunohistochemistry: ABCG8 Antibody (1B10A5) - IHC of ABCG8 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Mouse anti-Mouse Monoclonal (DY550) (1B10A5) Antibody
Mouse
ICC, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
ABCG8 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ABCG8 Antibody - Western blot analysis of extracts of A549 cell lines.
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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ABCG8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
0.2 ml/$386
ABCG8 Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution 1:100
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ABCG8 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
ABCG8 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ABCG8 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
ABCG8 Antibody
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ABCG8 Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
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ABCG8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
200 µl/$649
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ABCG8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$572
ABCG8 Antibody - Western blot of ABCG8, using ABCG8 antibody. Samples: mouse liver microsomes from G5/G8 knockout mice, wild type human G5/G8, and transgenic human G5/G8.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCG8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
0.1 ml/$386
ABCG8 Antibody - Western blot - Anti-ABCG8 Picoband Antibody
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
ABCG8 Antibody - Western blot testing of 1) rat liver, 2) mouse liver and 3) human placenta lysate with ABCG8 antibody at 0.5ug/ml. Predicted molecular weight ~76 kDa.
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ABCG8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$575
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).