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ABCE1

ATP-binding cassette, sub-family E (OABP), member 1

ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: ATP-binding cassette, sub-family E (OABP), member 1
Family/Subfamily: Transporter , ATP-binding cassette - ABCE/OABP
Synonyms: ABCE1, ABC38, HuHP68, Ribonuclease 4 inhibitor, RLI, RNASELI, OABP, RNASEL1, RNase L inhibitor, RNS4I
Target Sequences: NM_002940 NP_002931.2 P61221

Publications (1)

1
The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. Chen ZQ, Dong J, Ishimura A, Daar I, Hinnebusch AG, Dean M. The Journal of biological chemistry. 2006 281:7452-7. [PubMed:16421098]

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Products
Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
ABCE1 (8)
No (8)
GST (1)
GST, N-terminus (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
ABCE1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ABCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.1 kDa
20 µg/$150
ABCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.1 kDa
20 µg/$150
ABCE1 Protein - 12.5% SDS-PAGE of human ABCE1 stained with Coomassie Blue
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Wheat Germ Extract
GST
93.7 kDa
2 µg/$439
ABCE1 Protein - Purified recombinant protein ABCE1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
67.1 kDa
20 µg/$1,107
ABCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.1 kDa
100 µg/$494
ABCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.1 kDa
100 µg/$494
ABCE1 Protein - Recombinant ATP Binding Cassette Transporter E1 (ABCE1) by SDS-PAGE
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E. coli
His-T7, N-terminus
22.4kDa
10 µg/$267; 50 µg/$352; 200 µg/$705; 100 µg/$565; 1 mg/$1,728; 500 µg/$1,303; 5 mg/$2,680; 2 mg/$1,906
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).