ABCC8 / SUR1

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not yet been fully described.

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Proteins (3)

Type

Recombinant (3)

Target

ABCC8 / SUR1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (1)

Species

Human (3)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human ABCC8 / SUR1 Protein (Recombinant His) (aa679-929) - LS-G25337

Source:

E. coli

Tag:

His

Molecular Weight:

31.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human ABCC8 / SUR1 Protein (Recombinant GST, N-terminus) (aa611-710) - LS-G60255

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ABCC8 / SUR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67040

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

176.8 kDa

Price:

20 µg/$1,107

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