ABCC5 / MRP5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

ABCC5 / MRP5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ABCC5 / MRP5 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ABCC5 / MRP5 Protein (Recombinant GST) (Full Length) - LS-G31923

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ABCC5 / MRP5 Protein (Recombinant GST, N-terminus) (aa760-846) - LS-G61349

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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ABCC5 / MRP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121149

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.5 kDa

Price:

100 µg/$494

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Human ABCC5 / MRP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79810

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.5 kDa

Price:

20 µg/$150

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Human ABCC5 / MRP5 Protein (Recombinant His, N-Terminal) - LS-G145028

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.5 kDa

Price:

50 µg/$419

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