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ABCC5 / MRP5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCC5 / MRP5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
| Gene Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCC/MRP |
| Synonyms: | ABCC5, ABC33, Abcc5a, MOATC, MRP5, PABC11, SMRP, EST277145, MOAT-C |
| Target Sequences: | NM_005688 NP_005679.2 O15440 |
Publications (1)
1
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human)
[Full Text Article]
[PubMed:22734885]
[PMC:PMC3457850]
Related Antibodies: LS-B2334.
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ABCC5 / MRP5
(54)
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(48)
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ABCC5 / MRP5 Goat anti-Human Polyclonal (aa2-13) Antibody
Chicken, Bovine, Rabbit, Dog, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ABCC5 / MRP5 Mouse anti-Human Monoclonal (6C6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ABCC5 / MRP5 Rat anti-Mouse Monoclonal (aa1-38) (M5I-10) Antibody
Mouse
ICC, IHC, IHC-Fr, WB
Unconjugated
1 ml/$836
ABCC5 / MRP5 Rat anti-Human Monoclonal (Concentrated) (M5I-10) Antibody
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$522
ABCC5 / MRP5 Rat anti-Human Monoclonal (Concentrated) (M5II-54) Antibody
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$522
ABCC5 / MRP5 Rat anti-Human Monoclonal (Concentrated) (M5I-1) Antibody
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$522
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ABCC5 / MRP5 Mouse anti-Human Monoclonal (OTI2C8) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ABCC5 / MRP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI2C8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$331
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ABCC5 / MRP5 Mouse anti-Human Monoclonal (aa760-846) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
ABCC5 / MRP5 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
ABCC5 / MRP5 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
ABCC5 / MRP5 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
ABCC5 / MRP5 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
ABCC5 / MRP5 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
ABCC5 / MRP5 Rabbit-New Zealand White anti-Human Polyclonal (aa10-60) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
ABCC5 / MRP5 Rabbit-New Zealand White anti-Human Polyclonal (aa500-550) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
ABCC5 / MRP5 Rabbit anti-Human Polyclonal (aa631-661) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
ABCC5 / MRP5 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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