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ABCC3 / MRP3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Gene Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
Family/Subfamily: | Transporter , ATP-binding cassette - ABCC/MRP |
Synonyms: | ABCC3, ABC31, EST90757, MOAT-D, MLP2, Multidrug resistance protein 3, MRP3, CMOAT2 |
Target Sequences: | NM_003786 AAD02845.1 O15438 |
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