ABCC2 / MRP2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

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Proteins (2)

Type

Recombinant (2)

Target

ABCC2 / MRP2 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

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Human ABCC2 / MRP2 Protein (Recombinant GST, N-terminus) (aa214-313) - LS-G58164

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ABCC2 / MRP2 Protein (Recombinant His) (aa1300-1534) - LS-G25334

Source:

E. coli

Tag:

His

Molecular Weight:

29.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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