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ABCC12 / MRP9 is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
Gene Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 |
Family/Subfamily: | Transporter , ATP-binding cassette - ABCC/MRP |
Synonyms: | ABCC12, MRP9 |
Target Sequences: | NM_033226 NP_150229.2 Q96J65 |
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