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ABCA7

ATP-binding cassette, sub-family A (ABC1), member 7

ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.

Gene Name: ATP-binding cassette, sub-family A (ABC1), member 7
Family/Subfamily: Transporter , ATP-binding cassette - ABCA/ABC1
Synonyms: ABCA7, ABCA-SSN, Autoantigen SS-N, ABCX, Macrophage ABC transporter
Target Sequences: NM_019112 NP_061985.2 Q8IZY2

Publications (3)

1
Expression, localization, and functional model of cholesterol transporters in lactating and nonlactating mammary tissues of murine, bovine, and human origin. Mani O, Krner M, Sorensen MT, Sejrsen K, Wotzkow C, Ontsouka CE, Friis RR, Bruckmaier RM, Albrecht C. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 299:R642-54. (IHC-P; Mouse, Bovine, Human) [PubMed:20445153]
2
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content. Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, Fitzgerald ML, Kronenberg M, Hedrick CC. Scientific reports. 2017 7:40273. (WB; Mouse) [Full Text Article] [PubMed:28091533] [PMC:PMC5238393]
3
ABCA7 loss-of-function variants, expression, and neurologic disease risk. Allen M, Lincoln SJ, Corda M, Watzlawik JO, Carrasquillo MM, Reddy JS, Burgess JD, Nguyen T, Malphrus K, Petersen RC, Graff-Radford NR, Dickson DW, Ertekin-Taner N. Neurology. Genetics. 2017 January;3:e126. (Human) [Full Text Article] [PubMed:28097223] [PMC:PMC5217615]

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ABCA7 Protein - Recombinant ATP Binding Cassette Transporter A7 (ABCA7) by SDS-PAGE
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51.0kDa
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).