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AATK / AATYK contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | apoptosis-associated tyrosine kinase |
Family/Subfamily: | Protein Kinase , LMR |
Synonyms: | AATK, AATYK, AATYK1, CDK5-binding protein, Lemur tyrosine kinase 1, p35-binding protein, p35BP, KIAA0641, LMR1, LMTK1 |
Target Sequences: | AB014541 BAA31616.2 Q6ZMQ8 |
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