AATF

apoptosis antagonizing transcription factor

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

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Products

Antibodies (60)

Proteins (8)

ELISA Kits (7)

Type

Over-Expression Lysate (2)

Primary (60)

Recombinant (6)

Sandwich (7)

Target

AATF (75)

Reactivity

Human (52)

Mouse (21)

Rat (17)

Bat (3)

Bovine (4)

Chicken (1)

Chimpanzee (9)

Dog (7)

Gibbon (9)

Guinea pig (6)

Horse (6)

Monkey (5)

Non-Human Primate (1)

Pig (3)

Porcine (1)

Rabbit (7)

Sheep (2)

Xenopus (1)

Zebrafish (3)

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Application

IHC (16)

IHC-P (7)

WB (59)

DB (1)

ELISA (14)

ICC (1)

IF (5)

IP (3)

Peptide-ELISA (2)

Host

rabbit (57)

mouse (3)

Product Group

IHCPlus (2)

Isotype

IgG (30)

IgG1 (2)

IgG1,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (57)

Clone

3C7 (1)

AATF2B6 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

APC (3)

APC Conjugated (3)

Biotin Conjugated (8)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (8)

HRP Conjugated (8)

PE Conjugated (3)

Unconjugated (24)

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Epitope

aa237-523 (8)

aa240-438 (8)

aa273-477 (8)

N-Terminus (5)

aa171-220 (4)

aa481-530 (4)

10-90 aa, N-terminal (1)

aa10-59 (1)

aa125-175 (1)

aa510-C-term (1)

pSer477 (1)

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Publications

No (75)

Sample Type

Plasma (2)

Serum (2)

Tag

GST (2)

GST, N-terminus (1)

His-GST (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ AATF Antibody (clone 3C7) LS-B11447

(4.0) Rating

Antibody:

AATF Mouse anti-Human Monoclonal (3C7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ AATF Antibody LS-B438

(4.0) Rating

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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AATF Antibody (aa171-220) LS-B17062

Antibody:

AATF Rabbit anti-Human Polyclonal (aa171-220) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

AATF Antibody (aa171-220, HRP) LS-C426937

Antibody:

AATF Rabbit anti-Human Polyclonal (aa171-220) (HRP) Antibody

Reactivity:

Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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AATF Antibody (aa171-220, Biotin) LS-C426934

Antibody:

AATF Rabbit anti-Human Polyclonal (aa171-220) (Biotin) Antibody

Reactivity:

Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

AATF Antibody (aa171-220, FITC) LS-C426935

Antibody:

AATF Rabbit anti-Human Polyclonal (aa171-220) (FITC) Antibody

Reactivity:

Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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AATF Antibody (N-Terminus) LS-C353394

Antibody:

AATF Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

AATF Antibody (N-Terminus) LS-C31281

Antibody:

AATF Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

AATF Antibody LS-C660084

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

AATF Antibody LS-C804596

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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AATF Antibody (10-90 aa, N-terminal) LS-C382681

Antibody:

AATF Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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AATF Antibody LS-C211567

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (HRP) LS-C211568

Antibody:

AATF Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (Biotin) LS-C211570

Antibody:

AATF Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (FITC) LS-C211569

Antibody:

AATF Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

AATF Antibody LS-C211571

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (HRP) LS-C211573

Antibody:

AATF Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (Biotin) LS-C211574

Antibody:

AATF Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

AATF Antibody (FITC) LS-C211572

Antibody:

AATF Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

AATF Antibody LS-C406206

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

AATF Antibody LS-C823240

Antibody:

AATF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

AATF Antibody (clone AATF2B6) LS-C342329

Antibody:

AATF Mouse anti-Human Monoclonal (AATF2B6) Antibody

Reactivity:

Human

Applications:

DB, WB

Format:

Unconjugated

Price:

100 µg/$486

Select

AATF Antibody (aa125-175) LS-C287862

Antibody:

AATF Rabbit anti-Human Polyclonal (aa125-175) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

AATF Antibody (aa10-59) LS-C119287

Antibody:

AATF Rabbit anti-Human Polyclonal (aa10-59) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

AATF Antibody LS-C69199

Antibody:

AATF Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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