AAK1

AP2 associated kinase 1

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

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Products

Proteins (2)

Type

Recombinant (2)

Target

AAK1 (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human AAK1 Protein (Recombinant GST) (Full Length) - LS-G32647

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AAK1 Protein (Recombinant GST, N-terminus) (aa315-415) - LS-G61851

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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