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A4 / PLP2 is an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5.
Gene Name: | proteolipid protein 2 (colonic epithelium-enriched) |
Synonyms: | PLP2, A4, A4-LSB, A4LSB, Intestinal membrane A4 protein, Proteolipid protein 2 |
Target Sequences: | NM_002668 NP_002659.1 Q04941 |
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