A2M / Alpha-2-Macroglobulin

alpha-2-macroglobulin

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

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Products

Proteins (16)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (12)

Target

A2M / Alpha-2-Macroglobulin (16)

Publications

No (16)

Tag

GST, N-terminus (1)

His (9)

His, N-Terminal (2)

His,C-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (2)

Pig (1)

Rat (5)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (4)

Insect Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Mouse A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa157-389) - LS-G13220

Source:

E. coli

Tag:

His

Molecular Weight:

27.6 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa616-856) - LS-G13218

Source:

E. coli

Tag:

His

Molecular Weight:

28.4 kDa

Price:

10 µg/$251; 50 µg/$311; 100 µg/$402; 200 µg/$502; 1 mg/$1,365; 500 µg/$1,002; 5 mg/$2,254; 2 mg/$1,523

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Mouse A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa1053-1214) - LS-G13221

Source:

E. coli

Tag:

His

Molecular Weight:

19.7 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,489

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Pig A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa1097-1357) - LS-G13223

Source:

E. coli

Tag:

His

Molecular Weight:

30.6 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Rat A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa216-437) - LS-G13224

Source:

E. coli

Tag:

His

Molecular Weight:

26.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Rat A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa574-734) - LS-G13226

Source:

E. coli

Tag:

His

Molecular Weight:

19.5 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Rat A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa818-1048) - LS-G13227

Source:

E. coli

Tag:

His

Molecular Weight:

27.0 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human A2M / Alpha-2-Macroglobulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88032

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

163.28 kDa

Price:

20 µg/$150

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Human A2M / Alpha-2-Macroglobulin Protein (Recombinant GST, N-terminus) (aa641-730) - LS-G57658

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human A2M / Alpha-2-Macroglobulin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70800

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.8 kDa

Price:

20 µg/$1,107

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Human A2M / Alpha-2-Macroglobulin Protein (Recombinant His,C-terminus) (Met1-Ala1474) - LS-G140753

Source:

Insect Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

164 kDa

Price:

50 µg/$721

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A2M / Alpha-2-Macroglobulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123444

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

163.28 kDa

Price:

100 µg/$494

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Human A2M / Alpha-2-Macroglobulin Protein (Over-Expression Lysate His, N-Terminal) (Ser24-Ala1474) - LS-G136131

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~161 kDa

Price:

100 µg/$298

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Human A2M / Alpha-2-Macroglobulin Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Ser24-Ala1474) - LS-G136132

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~161 kDa

Price:

200 µl/$283

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Rat A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa772-1056) - LS-G24184

Source:

E. coli

Tag:

His

Molecular Weight:

35.6 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Rat A2M / Alpha-2-Macroglobulin Protein (Recombinant His) (aa620-750) - LS-G22774

Source:

Yeast

Tag:

His

Molecular Weight:

16.9 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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