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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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A1CF / ACF
APOBEC1 complementation factor
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.
| Gene Name: | APOBEC1 complementation factor |
| Synonyms: | A1CF, ACF65, ACF64, APOBEC-1 stimulating protein, APOBEC1 complementation factor, APOBEC1CF, ACF, Apo-B RNA editing protein, APOBEC1-stimulating protein, RP11-564C4.2, ASP |
| Target Sequences: | NM_014576 NP_055391.2 Q9NQ94 |
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