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| Catalog Number | Size | Price |
|---|---|---|
| LS-G136594-20 | 20 µg | $336 |
| LS-G136594-100 | 100 µg | $446 |
| LS-G136594-1 | 1 mg | $1,460 |
Human IGF1R / IGF1 Receptor Protein (Recombinant 6His, N-terminus) - LS-G136594
Human IGF1R / IGF1 Receptor Protein (Recombinant 6His, N-terminus) - LS-G136594
Description:
IGF1R / IGF1 Receptor Protein LS-G136594 is a Recombinant Human IGF1R / IGF1 Receptor produced in Yeast 763-931aa with 6His, N-terminus tag(s). For Research Use Only
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(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Description:
IGF1R / IGF1 Receptor Protein LS-G136594 is a Recombinant Human IGF1R / IGF1 Receptor produced in Yeast 763-931aa with 6His, N-terminus tag(s). For Research Use Only
Specifications
Type
Recombinant Protein
Target
IGF1R / IGF1 Receptor
Synonyms
IGF1R | CD221 antigen | CD221 | IGF1 Receptor | IGFR | IGF-I receptor | Soluble IGF1R variant 1 | Soluble IGF1R variant 2 | Type 1 IGF receptor | IGFIR | JTK13
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
6His, N-terminus
Region
763-931aa
Predicted Molecular Weight
21.4 kDa
AA Sequence
YNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYE
Expression System
Yeast
Source Species
Yeast
Purification
Greater than 85% by SDS-PAGE
Usage Summary
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways
Bio-Activity
Not Tested
Endotoxin
Not Tested
Presentation
Lyophilized from Tris, 50% Glycerol
Storage
Store at -80°C for up to 1 year. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About IGF1R / IGF1 Receptor
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Images
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Popular IGF1R / IGF1 Receptor Proteins
Source:
Human
Tag:
Myc-DDK (Flag)
Source:
E. coli
Tag:
His, N-Terminal
Source:
Human
Tag:
6His, N-terminus
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
