TAAR8 is an orphan GPCR that is a potential receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions. TAAR8 has been identified in brain astroglia, the amygdala, and leukocytes. References: Front. Pharmacol., 02 July 2018, DOI: 10.3389/fphar.2018.00680