SLC7A11 (cystine/glutamate transporter, Xc-, xCT) is a chloride-dependent cystine-glutamate antiporter involved in excitatory signaling, glutamate release and modulation of synaptic activity. In addition to glutamatergic neurotransmission, it is thought to support neuroprotective processes related to oxidative stress. Dysfunctional glutamate signaling in neurological disorders such as schizophrenia may involve impairment of SLC7A11. In immunohistochemistry, SLC7A11 has high expression in astrocytes of the basolateral amygdala and prefrontal cortex in the brain, and it is also found in the eye, with low levels of additional expression in immune, reproductive and gastrointestinal tissues. References: Pharmacological Reviews. 64 (3): 780–802, PMID: 22759795; Journal of Psychiatric Research. 72: 58–63, PMID: 26540405; Glia. 2018 May;66(5):951-970, PMID: 29350434; NPJ Schizophr. 2017 Sep 18;3(1):31, PMID: 28924227; Antioxid Redox Signal. 2013 Feb 10; 18(5): 522–555, PMID: 22667998