RAR-related orphan receptor A (RORA, NR1F1) is a key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. RORA interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. It is involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, it plays a role as a negative regulator of adipocyte differentiation, probably acting through dual mechanisms. It may suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. RORA is involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A, and it may inhibit cell growth in response to cellular stress. Finally, it may exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804