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PathPlusTM PDGFRA / PDGFR Alpha Antibodies
PDGFRA is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival, cell migration, chemotaxis in wound healing, and platelet activation and aggregation. Depending on the context, it promotes or inhibits cell proliferation and cell migration. It plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells and is required for normal skeleton development, the development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and the normal development of intestinal villi. In cancer, PDGFRA is overexpressed in gliomas, gastrointestinal stromal tumors (GIST), and ovarian, prostate, colon, lung, breast, bone and skin cancers. PDGFRA expression in ovarian cancer and chondrosarcoma is associated with shorter survival. In immunohistochemistry of normal tissue, PDGFRA is widely expressed throughout the body. References: J Cell Physiol. 1994 Feb; 158(2):381-9, PMID: 8106574; J Histochem Cytochem. 2016 Dec; 64(12): 785–810, PMID: 27837159; Am J Surg Pathol 2001;25:1520; Sci Rep. 2015 Dec 7;5:17948, PMID: 26639755

3 PathPlusTM Antibodies
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Antibodies (3)
Primary (3)
PDGFRA / PDGFR Alpha (3)
Human (2)
Mouse (1)
IHC (2)
IHC-P (3)
WB (2)
IP (1)
rabbit (3)
Product Group
PathPlus Cancer (3)
IgG (1)
polyclonal pc (3)
Unconjugated (3)
aa1000-C-term (1)
No (2)
Yes (1)
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Cancer
PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (aa1000-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$605
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PDGFRA / PDGFR Alpha Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Fast Shipping
PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Viewing 1-3 of 3 product results