Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
PCNA (Proliferating cell nuclear antigen) is a replication factor that plays critical roles in DNA replication and repair. It is a cofactor of DNA polymerase delta, and acts as a homotrimer to increase the processivity of leading strand synthesis during DNA replication. It is ubiquitinated in response to DNA damage, and involved in the RAD6-dependent DNA repair pathway. Antibodies to PCNA are used as a marker of cell proliferation. It is expressed in the nucleus of proliferating cell populations.
References: Enzymes 2016 39:231; Nature Reviews Mol Cell Biol 2014 14:269