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NOH-1S is a voltage-gated proton channel that mediates the H+ currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H+ ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
Gene Name: | NADPH oxidase 1 |
Synonyms: | NOX1, MOX1, MOX-1, NADPH oxidase 1 variant NOH-1L, NADPH oxidase homolog-1, NOH-1, NOH1, Mitogenic oxidase 1, NADPH oxidase 1, gp91-2, NOX-1 |
Target Sequences: | NM_007052 NP_008983.2 Q9Y5S8 |
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