Macrophage stimulating 1 receptor (c-met-related tyrosine kinase, MST1R) regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, it interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. It also plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804