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order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Desmin (DES) is a subunit of intermediate filaments in muscles that controls sarcomere architecture. Mutations in desmin that result in excess aggregation of the protein throughout the cell are associated with cardiomyopathy and myofibrillar myopathy diseases. In immunohistochemistry, desmin is commonly used as a mesenchymal marker and is useful for confirming myogenic origin of tissues and distinguishing smooth muscle tumors (desmin positive) from GIST (desmin negative). It is also positive in reactive mesothelial cells, skeletal muscle tumors, leiomyomas and rhabdomyosarcomas.
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