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PathPlusTM CTSB / Cathepsin B Antibodies
CTSB (Cathepsin B) is a lysosomal cysteine protease involved in proteolysis, protease activity enhancement, neurogenesis and memory function. CTSB is present in the perinuclear lysosomes of normal epithelial cells and non-malignant tumors. It is also found on the membranes of tumor cells including gliomas and oral squamous cell carcinomas, and it can be upregulated in cancer. Elevated levels of CTSB can result in inflammation and increased cell death and are correlated with seizures, memory loss and other neurodegenerative effects in brain injury and neurological diseases. Furthermore, CTSB is a marker of the dedifferentiated chondrocyte phenotype and contributes to cartilage destruction in osteoarthritis and pathological proteolysis in rheumatoid arthritis and cancer. In immunohistochemistry, CTSB has cytoplasmic positivity in all tissues. References: The Journal of Biological Chemistry. 285 (3): 2120–9, PMID: 19858192; PLoS One. 11 (3): e0152165, PMID: 27031837; Stem Cell Research. 12 (3): 716–29, PMID: 24699410; Cell Metabolism. 24 (2): 332–40, PMID: 27345423; Journal of Neuroscience Research. 88 (13): 2847–58, PMID: 20653046; Journal of Neurobiology. 56 (4): 315–27, PMID: 12918016.

3 PathPlusTM Antibodies
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Antibodies (3)
Primary (3)
CTSB / Cathepsin B (3)
Human (3)
Mouse (1)
Rat (1)
Monkey (1)
IHC (1)
IHC-P (3)
WB (3)
Flo (2)
IF (1)
Peptide-ELISA (1)
rabbit (2)
goat (1)
Product Group
Antibodies to Coronavirus-Associated Targets (3)
Coronavirus Antibodies Proteins cDNAs (3)
PathPlus Neuro (3)
polyclonal pc (3)
Unconjugated (3)
Internal (1)
Internal Region (1)
aa198-227 (1)
No (3)
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
CTSB / Cathepsin B Rabbit anti-Human Polyclonal (aa198-227) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
CTSB / Cathepsin B Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Flo, IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
CTSB / Cathepsin B Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC-P, WB
Unconjugated
50 µl/$460
Viewing 1-3 of 3 product results