CORO1A is a protein found in macrophages and is involved in phagocytosis, mitochondrial apoptosis and T-cell mediated immunity. It is an important component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. CORO1A also has important functions in circuit formation in the developing nervous system; it helps to ensure that axons form stable connections and prevents overgrowth by suppressing the sympathetic neuron growth rate. Separately, expression of CORO1A has been found to be negatively associated with age in humans. In immunohistochemistry, CORO1A has highest cytoplasmic positivity in lymphoid tissue, followed by expression in the cerebral cortex, hippocampus and caudate in the brain, as well as limited positivity in the skin and a few other tissues. References: Aging Cell. 8 (3): 239–50, PMID: 19245677; Biochemistry. 48. pp. 116–23, PMID: 18925376; J Neurosci. 2015 Mar 4; 35(9): 3893–3902, PMID: 25740518