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Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Gene Name: | collagen, type VIII, alpha 1 |
Family/Subfamily: | Collagen , not assigned-Collagen |
Synonyms: | COL8A1, Collagen VIII Alpha 1, Endothelial collagen, C3orf7, Collagen alpha-1(VIII) chain, Collagen, type VIII, alpha 1 |
Target Sequences: | NM_001850 NP_001841.2 P27658 |
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