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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PathPlusTM Alpha-1-Antichymotrypsin Antibodies
SERPINA3 (Alpha-1-Antichymotrypsin) is an alpha globulin glycoprotein produced in the liver that functions as a plasma serine protease inhibitor. It functions in tissue repair and helps reduce damage resulting from inflammatory proteolysis. It is also involved in regulating proliferation and chromatin condensation. Mutations in SERPINA3 are associated with Alzheimer's disease, Parkinson’s disease and chronic obstructive pulmonary disease. Deficiency is correlated with liver disease, while upregulation of SERPINA3 potentially plays a role in the progression of prion diseases. Upregulated SERPINA3 is also associated with invasive properties and progression in glioblastoma. SERPINA3 is an inflammatory marker, and in immunohistochemistry of normal tissue it is positive in the cytoplasm and in extracellular deposits in histiocytes and reticulum cells. In cancer, it is positive in glioblastoma, acinar cell carcinomas of the pancreas, salivary gland and breast, and hepatoid adenocarcinomas of the stomach. References: Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID: 26553804; Scientific Reports. 2017. 7 (15637), DOI: 10.1038/s41598-017-15778-8; Gastroenterology 2013;144:818, PMID: 23295442; Australian & New Zealand Journal of Psychiatry. 2014. Vol. 48(8): 722–734, DOI: 10.1177/0004867414531078; Oncol Lett. 2018 Jan; 15(1): 285–291, PMID: 29399139

4 PathPlusTM Antibodies
☰ Filters
Antibodies (4)
Primary (4)
Alpha-1-Antichymotrypsin (4)
Human (4)
IHC (4)
IHC-P (4)
WB (3)
Flo (1)
ELISA (3)
ID (1)
IP (2)
rabbit (1)
mouse (2)
goat (1)
Product Group
PathPlus Cancer Pathology (4)
PathPlus Neuro (4)
IgG (1)
IgG1,k (1)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (2)
1C10 (1)
1E6 (1)
Unconjugated (4)
aa254-303 (1)
No (3)
Yes (1)
Alpha-1-Antichymotrypsin Antibody - Anti-SERPINA3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
Cancer Pathology
Alpha-1-Antichymotrypsin Rabbit anti-Human Polyclonal (aa254-303) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Alpha-1-Antichymotrypsin Antibody - Anti-SERPINA3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Neuroscience
Cancer Pathology
Alpha-1-Antichymotrypsin Mouse anti-Human Monoclonal (1C10) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Alpha-1-Antichymotrypsin Antibody - Anti-SERPINA3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Neuroscience
Cancer Pathology
Alpha-1-Antichymotrypsin Mouse anti-Human Monoclonal (1E6) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$555
Alpha-1-Antichymotrypsin Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
Cancer Pathology
Alpha-1-Antichymotrypsin Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IHC-P, IP, WB
Unconjugated
0.5 mg/$460
Viewing 1-4 of 4 product results