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| Catalog Number | Size | Price |
|---|---|---|
| LS-B655-50 | 50 µg (1.13 mg/ml) | $515 |
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2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human TGFB1 / TGF Beta 1 Antibody (IHC, IF, WB) LS‑B655
PathPlus™ Polyclonal Rabbit anti‑Human TGFB1 / TGF Beta 1 Antibody (IHC, IF, WB) LS‑B655
Note: This antibody replaces LS-C19008, LS-C89653, LS-C122495
Antibody:
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, IF, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, IF, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TGFB1 (TGF Beta 1, transforming growth factor beta 1), also known as LAP (Latency-associated peptide), is a secreted ligand of the TGF-beta family of proteins. TGFB1 is involved in activating a number of signal pathways (including the SMAD family of transcription factors) that regulate gene expression. TGFB1 regulates the inhibition of cell proliferation, and in normal tissues acts as a tumor suppressor. In later stage cancers, increased expression and higher serum levels have correlated with neoplastic progression, cell migration, and angiogenesis.
References: J Transl Med 2012 10:183
Target
Human TGFB1 / TGF Beta 1
Synonyms
TGFB1 | CED | DPD1 | Diaphyseal dysplasia 1 | LAP | Latency-associated peptide | TGF Beta | TGFbeta | TGF-beta 1 protein | TGF-beta-1 | TGFB
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Mammal (at least 90% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
TGF beta 1 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of the mature growth factor (112 amino acids in length).
Specificity
A BLAST analysis was used to suggest reactivity with this protein from most mammalian sources based on 100% homology for the immunogen sequence. Cross-reactivity is expected with TGFb1 from non-mammalian sources as only a single amino acid residue change is found within the immunogen sequence from many other organisms.
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Immunofluorescence
- Western blot (1:100 - 1:500)
- ELISA (1:10000 - 1:20000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B655 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B655 was determined to be 5 ug/ml.
Presentation
0.02 M Potassium Phosphate, pH 7.2, 0.15 M NaCl, 0.01% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TGFB1 / TGF Beta 1
Validation
Anti-TGFB1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TGFB1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
See More About...
LSBio Ratings
PathPlus™ TGFB1 / TGF Beta 1 Antibody for IHC, IF/Immunofluorescence, WB/Western, ELISA LS-B655 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human, Mouse
Applications:
Western blot, ELISA
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/27/2024
Date Requested: 11/27/2024
