WWOX (WW domain-containing oxidoreductase) is a protein involved in protein degradation, transcription, RNA splicing, neuronal differentiation and survival, apoptosis, and steroid, bone and glucose metabolism. WWOX has highest expression in the testes, ovaries and prostate. It is involved in neuronal development in the cerebral cortex, and it is expressed in neurons, astrocytes and oligodendrocytes in the brain. Mutations in WWOX lead to infant neurological disorders, stunted growth, epilepsy, and premature death. In Alzheimer’s patients, WWOX is often downregulated in the brain and lowered levels of WWOX may contribute to neurodegeneration. In immunohistochemistry, WWOX has cytoplasmic positivity in most tissues throughout the body. References: Exp Biol Med (Maywood). 2015 Mar; 240(3): 345–350, PMID: 25491415; Front Neurosci. 2018 Aug 15;12:563, PMID: 30158849;