UTS2R is a high affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. Functionally, UTS2R is involved in regulating autophagy and plays a role in chemotactic migration. Binding of UTS2 to UTS2R may stimulate the migration of neoplastic cells of various cancers including colorectal cancer, prostate cancer, and glioma. In immunohistochemistry, UTS2R has membranous positivity in the thyroid gland, the cerebral cortex in the brain, the testes, heart and skeletal muscle, and low levels of expression in the gastrointestinal tract and a few other tissues throughout the body. References: Autophagy. 2016; 12(12): 2344–2362, PMID: 27715446