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| Catalog Number | Size | Price |
|---|---|---|
| LS-B2473-250 | 250 µl (0.2 mg/ml) | $485 |
PathPlus™ Monoclonal Mouse anti‑Human Tyrosinase Antibody (clone T311, IHC, IF, WB) LS‑B2473
PathPlus™ Monoclonal Mouse anti‑Human Tyrosinase Antibody (clone T311, IHC, IF, WB) LS‑B2473
Note: This antibody replaces LS-C18403
Antibody:
Tyrosinase Mouse anti-Human Monoclonal (T311) Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Cat, Dog
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
Tyrosinase Mouse anti-Human Monoclonal (T311) Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Cat, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
Tyrosinase (TYR) is an enzyme that catalyzes steps in the conversion of tyrosine to melanin. Mutations in TYR results in oculocutaneous albinism, and polymorphisms results in variations in skin pigmentation. The protein is found in melanocytes in the skin and retina, and is useful to identify melanocytic neoplasms such as melanomas. It is also found in subsets of renal angiomyolipomas and PEComas.
References: PNAS USA 1995 92:8125; Arch Path Lab Med 2007 131(1):122; Arch Path Lab Med 2009 133:648
Target
Human Tyrosinase
Synonyms
TYR | CMM8 | LB24-AB | SHEP3 | SK29-AB | Monophenol monooxygenase | Tumor rejection antigen AB | OCA1A | Tyrosinase | OCAIA
Host
Mouse
Reactivity
Human, Cat, Dog
(tested or 100% immunogen sequence identity)
Clonality
IgG2a
Monoclonal
Clone
T311
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Immunogen
Recombinant tyrosinase protein. Epitope: 1-433.
Specificity
Recognizes a cluster of proteins between 70-80kD, identified as human tyrosinase. Occasionally a minor band at 55kD is also detected. Does not cross-react with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Species cross-reactivity: canine and feline. Weak cross-reactivity with mouse.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- ICC
- Immunofluorescence
- Western blot (1 - 2 µg/ml)
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B2473 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2473 was determined to be 10 ug/ml.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide, 0.2% BSA
Storage
Short term: 4°C Long term: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About Tyrosinase
Validation
Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
PathPlus™ Tyrosinase Antibody (clone T311) for IHC, ICC, IF/Immunofluorescence, WB/Western, ELISA LS-B2473 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human, Mouse
Applications:
IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/27/2024
Date Requested: 11/27/2024
