Thyrotropin-releasing hormone receptor (TRHR) is a receptor that binds thyrotropin-releasing hormone (TRH) and is involved in exocytosis of thyroid-stimulating hormone (TSH) into the blood. TRHR can be used as a marker to identify specific (TRHR positive) subtypes of direction-selective retinal ganglion cells, involved in directional visual motion detection. Inherited mutations in TRHR are associated with congenital hypothyroidism. In immunohistochemistry, TRHR has membranous and cytoplasmic positivity in populations of thyrotropes in the anterior pituitary gland, and it is also present in the cerebral cortex. References: J Neurosci. 2011 Jun 15; 31(24): 8760–8769, PMID: 21677160; OMIM. Johns Hopkins University, Baltimore, MD. 09/06/2019. MIM Number: 188545;