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Catalog Number Size Price
LS-B16536-0.05 0.05 ml $460 
Thyrotropin / TSH Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Monoclonal Mouse anti‑Human Thyrotropin / TSH Antibody (IHC) LS‑B16536

PathPlus™ Monoclonal Mouse anti‑Human Thyrotropin / TSH Antibody (IHC) LS‑B16536

Note: This antibody replaces LS-C312197
Antibody:
Thyrotropin / TSH Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B16536-0.05
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
Thyrotropin / TSH Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Thyroid-stimulating hormone (thyrotropin, TSH) is a glycoprotein hormone produced in the pituitary gland. TSH serves to stimulate the thyroid to produce thyroxine and its converted product triiodothyronine, which in turn stimulate metabolism throughout the body. High levels of TSH are secreted during stress, development and rapid growth. TSH is a heterodimer, and the beta subunit (TSHB) is unique to thyroid-stimulating hormone, while the alpha subunit (TSHA) is identical across chorionic gonadotropin, luteinizing hormone and follicle-stimulating hormone. Levels of TSH are commonly measured to determine degree of thyroid function and to diagnose diseases of the thyroid. In immunohistochemistry, antibodies to TSH are used to identify and subtype pituitary adenomas; roughly 1% of pituitary adenomas have been found to secrete excess TSH, which leads to downstream overproduction of thyroid hormones and consequently hyperthyroidism. In normal tissue, TSH has positive cytoplasmic staining in anterior pituitary endocrine cells. References: Clin Med Res. 2016 Jun;14(2):83-92, PMID: 27231117; J Endocrinol Invest. 2018 Apr;41(4):447-454, PMID: 29022276
Target
Human Thyrotropin / TSH
Synonyms
TSH
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated
Purification
Ig fraction
Modifications
Unmodified
Applications
  • IHC - Paraffin (1:50)
  • IHC - Frozen (1:250 - 1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: Paraffin and frozen. Control tissue: Pituitary. Localization: Cytoplasmic.
Presentation
Filter sterilized and diluted in buffer, pH 7.5, BSA, Sodium Azide
Storage
Store at 2-8°C. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

Validation

Thyrotropin / TSH Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ Thyrotropin / TSH Antibody for IHC LS-B16536 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/4/2024