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SNCA / Alpha-Synuclein
synuclein, alpha (non A4 component of amyloid precursor)
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
| Gene Name: | synuclein, alpha (non A4 component of amyloid precursor) |
| Synonyms: | SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein |
| Target Sequences: | NM_000345 NP_000336.1 P37840 |
Publications (7)
1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9.
[PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB)
[PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32.
[PubMed:22033456]
[PMC:PMC3237852]
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SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pS129) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Mouse anti-Human Monoclonal (aa1-140) (5C2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (aa1-140) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Sheep, Mouse, Dog, Rat, Pig, Human
IHC-P, WB
Unconjugated
50 µl/$460
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer129) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$440; 100 µg/$480
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer87) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Goat anti-Human Polyclonal (aa91-102) Antibody
Mouse, Hamster, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SNCA / Alpha-Synuclein Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$786
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Yeast
6His, N-terminus
16.5 kD
500 µg/$1,411; 100 µg/$679; 20 µg/$429
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
SNCA / Alpha-Synuclein Chicken anti-Human Polyclonal Antibody
Rat, Pig, Cow, Horse, Mouse, Human
ICC, IF, WB
Unconjugated
100 µl/$376
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Goat anti-Human Polyclonal (aa97-110) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SNCA / Alpha-Synuclein Mouse anti-Mouse Monoclonal (4F1) Antibody
Mouse, Rat, Human
DB, ELISA, IF, IHC, WB
Unconjugated
100 µg/$442
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer129) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100 µg/$570
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$311; 20 µg/$245; 1 mg/$511
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