SNAP25 (synaptosomal nerve-associated protein 25) is a t-SNARE protein. Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). This gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Deletions in this gene are associated with hyperactive and attention deficit disorders in mice and may lead to ADHD in humans, and mutations in SNAP25 have also been linked with other neuropsychiatric disorders including schizophrenia and epilepsy. In immunohistochemistry of normal tissue, SNAP25 has high positivity in the cerebral cortex in the brain. References: Mol. Psychiatry. 7 (8): 913–7, PMID: 12232787; Neuroscience. 2018 Sep 27, PMID: 30267828